Step 1: Extract the downloaded zip file into a folder
Step 2: Open the executable
Step 3: Click 'Locate' to find your lol executable, it will open an explorer window, just click your lol.launcher file.
Step 4: Choose the mods you want
Step 5: Click Patch, and your done! Enjoy your mods
To remove patches - click remove/uninstall in the program or just update league of legends with the repair tool